Data published in The Lancet showed a survival benefit in nonsquamous patients with advanced non-small cell lung cancer (NSCLC) who received maintenance therapy with ALIMTA (pemetrexed for injection) plus best supportive care as compared to placebo plus best supportive care. This Phase III clinical trial supported previous studies looking at...

Neogenix Oncology, Inc. (Neogenix) announced that NPC-1C, the company's first IND (Investigational New Drug Application) was granted permission by the Food and Drug Administration (FDA) for the company to begin a Phase I trial. NPC-1C is derived from a colorectal cancer vaccine that had previously demonstrated safety and clinical activity...

Mary Foust knew something was wrong eight years ago. She was feeling bloated, fatigued and had pain in her abdomen. "They're all things that women have, so it's real easy to ignore them," Foust said. Foust, uneasy about the symptoms she felt, scheduled a doctor's appointment, but first planned to...

Marking a major milestone in the early detection and management of colon cancer, EDP Biotech Corporation (EDP), a developer of immunodiagnostic tests for humans and animals, announced that its ColoMarker" assay achieved 100 percent detection rate for colon cancers presented at stages I through III in pre-clinical trials. ColoMarker is...

The U.S. Food and Drug Administration (FDA) today cleared the OVA1" Test, the first blood test that, prior to surgery, can help physicians determine if a woman is at risk for a malignant pelvic mass. OVA1 is the first FDA-cleared laboratory test that can indicate the likelihood of ovarian cancer...

Most people know that there are many benefits to maintaining a healthy diet. Longer lives, disease prevention and an ideal weight are all results of eating healthy. But how can you know which foods to buy -- let alone which foods to eat? Now it may be easier than ever...

America's most popular vegetables - golden brown french fries and crispy potato chips - aren't just loaded with fat and sodium. Starchy fried foods also can contain a chemical called acrylamide that is quietly raising concern as a potential human carcinogen. A natural byproduct of cooking high-carbohydrate foods at high...

NEWPORT NEWS, Va. -- "We were ready to start a family when a mammogram revealed an abnormal mass in my left breast," said Staci Sansolo, 34, of New Jersey. A biopsy revealed the mass was not cancer, but a second-round test found another area of concern. Due to family history...

Can your breath help diagnose breast cancer? Researchers from the Georgia Tech Research Institute and Emory Winship Cancer Institute think it might. They are adapting a process typically used in Europe to test for occupational exposure to contaminants and using it to detect the presence of breast cancer. In a...

WEST LAFAYETTE, Ind. -- Although breast cancer remains one of the most-often diagnosed cancers in women each year, methods to improve the detection and elimination of cancerous cells are being discovered, developed and tested each day around the world with plans to deliver them to tomorrow's markets, say researchers at...

According to a study from the United States, "The Janus kinase 2 (Jak2) is essential for normal mammary gland development, but this tyrosine kinase and its main effector, signal transducer and activator of transcription 5, are also active in a significant subset of human breast cancers. We have recently reported...

"The majority of cancer mortality is attributed to metastasis, which is the spread of tumor cells to a secondary site," scientists in the United States report. "Several studies have demonstrated that the genetic background on which a tumor arises has a major effect on both metastatic efficiency and on predictive...

RALEIGH, N.C. -- U.S. medical scientists say they have determined how physicians can lowers their costs and reduce waiting times for patients undergoing colonoscopies. Colorectal cancer is a leading cause of cancer-related deaths in the United States, but the disease can be managed with early screening using a procedure called...

According to recent research from Vienna, Austria, "Sporadic colorectal cancer is a disease of advancing age and the percentage of the population which reaches an advanced age is strongly, increasing. Multiple factors are responsible for the etiology of this cancer since the colorectal mucosa is directly influenced by, nutrients reaching...

"Genetic variability in drug-metabolizing enzymes and signaling pathways affects chemotherapy-related toxicity and treatment outcome in cancer. in breast and colorectal. cancer, polymorphisms in metabolic enzymes involved in tamoxifen and irinotecan therapies has led the U.S. Food and Drug Administration to address genetic factors relevant to patient consideration of treatment with...

Research findings, 'Cumulative risk of colon cancer up to age 70 years by risk factor status using data from the Nurses' Health Study,' are discussed in a new report. "The authors developed a comprehensive model of colon cancer incidence that allows for nonproportional hazards and accounts for the temporal nature...

Although overall incidence and death rates from colorectal cancer are decreasing, the gap in death rates between African-Americans and Caucasians has widened. Colorectal cancer is the third most common cancer among both African-American men and women, however, it is preventable and some screening programs within the African-American community are working...

SCOTTSDALE, Ariz. -- A U.S. Phase 1 clinical trial is under way to determine if a new anti-cancer drug is safe and effective for use in patients with solid cancer tumors. The drug, currently called EP-100, is designed to treat common breast, prostate, endometrial, pancreatic, ovarian, skin and testicular cancers....

According to recent research from the United States, "The absence of highly sensitive and specific serum biomarkers makes mass screening for ovarian cancer impossible. The claudin proteins are frequently overexpressed in ovarian cancers, but their potential as prognostic, diagnostic, or detection markers remains unclear." "Here, we have explored the possible...

RICHMOND, British Columbia -- Whispering Oaks International, Inc., d/b/a Biocurex, announced today that it is making two presentations at the annual meeting of the International Society of Oncology and Biomarkers (ISOBM) being held this week in Amsterdam, The Netherlands. BioCurex's presentations address its RECAF cancer market test in combination with...

Cervical cancer could be eradicated within the next 50 years if countries implement national screening programmes based on detection of the human papilloma virus (HPV), which causes the disease, together with vaccination programmes against the virus, according to a cervical cancer screening expert. Professor Jack Cuzick told Europe's largest cancer...

Cell Therapeutics, Inc. announced that it will re-focus its resources on the approval of OPAXIO" for its potential superiority indication in maintenance therapy for ovarian cancer. The Gynecologic Oncology Group (GOG) is conducting an ongoing phase III trial that evaluates the use of 12 months of OPAXIO therapy versus an...

COLD SPRING HARBOR, N.Y. -- U.S. scientists say they have discovered a group of genes that act as barriers against cancer development. Cold Spring Harbor Laboratory researchers said they used a powerful technology called RNA interference, which suppresses gene activity, to screen hundreds of candidate tumor suppressors in living mice,...

According to recent research from the United States, "Negative regulatory mechanisms within the solid tumor microenvironment inhibit antitumor T-cell function, leading to evasion from immune attack. One inhibitory mechanism is up-regulation of programmed death-ligand 1 (PD-L1) expressed on tumor or stromal cells which binds to programmed death-1 (PD-1) on activated...

In this recently published study, investigators in the United States conducted a study "To evaluate the patterns and timing of initial recurrence in patients with Hodgkin's lymphoma (HL) who subsequently underwent high-dose chemotherapy with autologous stem cell transplantation to enhance our understanding of the natural history of this disease and...

"The past decade has witnessed a paradigm shift in the initial treatment of multiple myeloma with the introduction of novel agents such as thalidomide, lenalidomide, and bortezomib, leading to improved outcomes. High-dose therapy and autologous stem cell transplantation remains an important therapeutic option for patients with multiple myeloma eligible for...

The U.S. Food and Drug Administration has approved Folotyn (pralatrexate), the first treatment for a form of cancer known as Peripheral T-cell Lymphoma (PTCL), an often aggressive type of non-Hodgkin's lymphoma. Folotyn was approved under the FDA's accelerated approval process, which allows earlier approval of drugs that meet unmet medical...

TUSTIN, Calif. -- Peregrine Pharmaceuticals, Inc. today reported additional positive results in its Phase II trial evaluating bavituximab in combination with carboplatin and paclitaxel in patients with non-small cell lung cancer (NSCLC). Data previously reported from the initial cohort of 21 patients in the study had indicated that 11 of...

Patients with advanced non-small cell lung cancer who are given cetuximab (Erbitux) in addition to chemotherapy are 13% less likely to die than those who receive chemotherapy alone, regardless of which chemotherapy drug cocktail is used, new research finds. They also experience slower disease progression and an increased chance of...

Data published in The Lancet showed a survival benefit in nonsquamous patients with advanced non-small cell lung cancer (NSCLC) who received maintenance therapy with ALIMTA (pemetrexed for injection) plus best supportive care as compared to placebo plus best supportive care. This Phase III clinical trial supported previous studies looking at...

PHILADELPHIA -- Smokers who learn their personal risk of lung cancer through gene-based risk assessment are more likely to be motivated to quit their habit, according to Dr. W. Jeffrey Allard, clinical affairs director of Synergenz Bioscience Ltd. The Respiragene(TM) test, which uses genetic markers and clinical variables to tell...

The doctors told Susan Smedley Gerber that her lung cancer wasn't caused by smoking but in many ways it didn't matter. She found herself facing the same stigma and same reactions that thousands of lung cancer patients fight in addition to their cancer. "So much of the stigma that's connected...

Over the last several years, unprecedented numbers of men have elected to undergo robotically assisted surgery for prostate cancer in the belief that the less invasive approach would give them a better chance of maintaining normal sexual function and avoiding incontinence. Serving as a warning of how medical marketing and...

SCOTTSDALE, Ariz. -- A U.S. Phase 1 clinical trial is under way to determine if a new anti-cancer drug is safe and effective for use in patients with solid cancer tumors. The drug, currently called EP-100, is designed to treat common breast, prostate, endometrial, pancreatic, ovarian, skin and testicular cancers....

A new guide, Straight Talk for African-American Men and their Families, is now available from the Prostate Cancer Foundation (PCF). It was produced in alliance with Charlie Wilson, famed R&B; singer and recent prostate cancer survivor. African-American men are 1.6 times more likely to be diagnosed with prostate cancer and...

According to recent research from the United States, "Dietary intake of genistein by patients with prostate cancer has been associated with decreased metastasis and mortality. Genistein blocks activation of p38 mitogen-activated protein kinase and thus inhibits matrix metalloproteinase-2 (MMP-2) expression and cell invasion in cultured cells and inhibits metastasis of...

SUNNYVALE, Calif. -- Accuray Incorporated, a global leader in the field of radiosurgery, announced today publication of results from a study of early stage prostate cancer patients treated with CyberKnife Radiosurgery. The study demonstrated that erectile function was preserved in 81 percent of patients at a median follow-up of two...

"Pancreatic cancers contain exclusively tumorigenic cancer stem cells (CSCs), which are highly resistant to chemotherapy, resulting in a relative increase in CSC numbers during gemcitabine treatment. Signaling through sonic hedgehog and mammalian target of rapamycin (mTOR), respectively, may be essential for CSC self-renewal and could represent putative targets for novel...

SCOTTSDALE, Ariz. -- A U.S. Phase 1 clinical trial is under way to determine if a new anti-cancer drug is safe and effective for use in patients with solid cancer tumors. The drug, currently called EP-100, is designed to treat common breast, prostate, endometrial, pancreatic, ovarian, skin and testicular cancers....

For the first time researchers have shown that by inhibiting the action of an enzyme called TAK-1, it is possible to make pancreatic cancer cells sensitive to chemotherapy, opening the way for the development of a new drug to treat the disease. Dr Davide Melisi told Europe's largest cancer congress,...

"Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that is overexpressed in many types of tumors, including pancreatic cancer, and plays an important role in cell adhesion and survival signaling. Pancreatic cancer is a lethal disease and is very resistant to chemotherapy, and FAK has been shown recently to...

Neogenix Oncology, Inc. (Neogenix) announced that NPC-1C, the company's first IND (Investigational New Drug Application) was granted permission by the Food and Drug Administration (FDA) for the company to begin a Phase I trial. NPC-1C is derived from a colorectal cancer vaccine that had previously demonstrated safety and clinical activity...

DURHAM, N.C. -- U.S. scientists say they've found a genetic alteration is the cause of familial chordoma, an uncommon bone cancer that also affects the nervous system. Duke University Medical Center and National Cancer Institute researchers said the genetic alteration -- a second copy of an entire gene -- produces...

LOS ANGELES -- Physical activity in adolescence is associated with a lower risk of developing brain tumors in adulthood, a new study suggests. Exercising later in life, however, didn't seem to matter, according to the study published by HealthDay News on Tuesday. The study also found that avoiding obesity during...

Data published in The Lancet showed a survival benefit in nonsquamous patients with advanced non-small cell lung cancer (NSCLC) who received maintenance therapy with ALIMTA (pemetrexed for injection) plus best supportive care as compared to placebo plus best supportive care. This Phase III clinical trial supported previous studies looking at...

The doctors told Susan Smedley Gerber that her lung cancer wasn't caused by smoking but in many ways it didn't matter. She found herself facing the same stigma and same reactions that thousands of lung cancer patients fight in addition to their cancer. "So much of the stigma that's connected...

"The uptake of risk-reducing surgery in women at increased risk of breast and ovarian cancer is highly variable between countries and centers within countries. We have investigated the rate, timing, and age of uptake of surgery in the northwest of U.K. to report the results after up to 7 years...

M. D. Anderson Cancer Center is taking action to safeguard its patients, their families and the health care teams from added exposure to H1N1 and seasonal flu.  Effective Monday, Oct. 19, M. D. Anderson will not allow visitors 12 years and under in any of its campus buildings or common...

Because a cancer diagnosis spurs a raft of questions for patients and caregivers, Anderson Network has arranged week-long online sessions with many of our experts in specific types of cancer.   The current forum addresses bladder cancer, its new treatment options and results. The fourth most common type of cancer in...

If ever there was a breast cancer in need of increased awareness, it's inflammatory breast cancer. IBC, also known as the silent killer, is a quickly spreading cancer that starts on the skin. Most of the time, there's no lump. This post is short and sweet with one take-home message...

It takes some imagination to grasp the raw computational challenge researchers face trying to understand the molecular causes of cancer. John Weinstein, M.D., Ph.D., professor and chair of M. D. Anderson's Department of Bioinformatics and Computational Biology, likes to start with this imagery."If you unpacked the DNA in every cell...

It's been 10 years since the Children's Art Project at M. D. Anderson Cancer Center published a story book, but this year they're at it again with "Our Shadow Garden."The latest story book is both educational and an interesting read. The storyline focuses on a grandmother who loves to garden,...

Ellen Gritz, Ph.D., Professor in the Department of Behavioral Science, and Janis Apted, Assoc VP for Faculty Development, both at M. D. Anderson, discuss the new book 'Academic Medicine: In Sickness and in Health - Scientists, Physicians, and the Pressures... ...

Medical Oncology and Reza Mehran, CD, SBStJ, M.D.C.M., MSc, FRCSC, FACS, Professor, Department of Thoracic and Cardiovascular Surgery, discuss the latest advances in treating mesothelioma.... ...

Lorenzo Cohen, Ph.D., director of M. D. Anderson's Integrative Medicine Program, and Peiying Yang, Ph.D., asssistant professor in the Integrative Medicine program, discuss the in-roads traditional Chinese medicine has made in western medicine and cancer treatment.... ...

Dr. Allen Burton, chair of the Department of Pain Medicine at M. D. Anderson, speaks about cancer pain management. About one-third of patients being treated for cancer experience pain and it can take many forms. Whether chronic or acute, pain... ...

Mary Donnelly Jackson, program coordinator for M. D. Anderson's Volunteer Services, describes a way you can help that doesn't involve money - volunteering.... ...

Contrary to concerns that the human papillomavirus vaccine might promote promiscuity, a national survey of girls and young women observed that the majority of respondents did not believe the HPV vaccine protected them against other sexually transmitted infections. The study, conducted by University of Illinois...

Cervical cancer could be eradicated within the next 50 years if countries implement national screening programmes based on detection of the human papilloma virus (HPV), which causes the disease, together with vaccination programmes against the virus, as per a cervical cancer screening expert. Professor Jack...

There are currently about fifty million smokers in the U.S. and there are another fifty million ex-smokers. Cigarette smoking has been linked to several human malignancies. Some of these links like the relationship between smoking and lung cancer are well established. In some other cases...

Less than half of Ontario women with abnormal Pap tests receive recommended and potentially life-saving follow-up care, as per a new women's health study by scientists at St. Michael's Hospital and the Institute for Clinical Evaluative Sciences (ICES). What's more, low-income women are less likely...

A test for the two strains of human papillomavirus responsible for most cervical cancers is under study. The molecular assay uses a cervical scraping, like that for a liquid-based Pap smear, to test for HPV types 16 and 18, responsible for 70 percent of cervical...

With a novel therapeutic delivery system, a research team led by researchers at The University of Texas M. D. Anderson Cancer Center has successfully targeted a protein that is over-expressed in ovary cancer cells. Using the EphA2 protein as a molecular homing mechanism, chemotherapy was...

Recurrent and metastatic endometrial and ovary cancers can be notoriously difficult to treat: They have spread to other organs and typically have developed resistance to chemotherapy; and patients already heavily treated with chemotherapy may not be able to endure more chemo. Now, physicians at Albert...

Kisspeptin and its receptor GPR54 predict a favourable clinical outcome in women with ovarian carcinoma, and are specific for the clear cell carcinoma subtype, research published this week in the online open access journal, BMC Medicine, reveals. The kisspeptins, a family of peptide hormones, and...

The only available screening tests for ovary cancer fail to catch early signs of the disease and often result in unnecessary surgery, said scientists at the University of Alabama at Birmingham (UAB) Comprehensive Cancer Center. The newly released study looked at a screening regimen that...

Scientists at Yale School of Medicine have developed a blood test with enough sensitivity and specificity to detect early stage ovary cancer with 99 percent accuracy. Results of this new study are reported in the February 15 issue of the journal Clinical Cancer Research. The...